This series offers a uniquely interactive online introduction to the field of substance misuse prevention. Participants examine the history of substance misuse prevention, key concepts, and foundational research informing the Strategic Prevention Framework, SAMHSA’s five-step, data-driven planning process. Training participants build basic knowledge and skills necessary to identify prevention priorities and develop a plan to implement and evaluate evidence-based interventions. This online consultation series offers structured skill-based learning opportunities, individual reading and learning assignments, group activities, and discussions to enhance learning application and outcomes.